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The Executive Officer and Director of OMS is Jay Toven.

Specifically, OMS provides leadership, oversight, and executive support for human capital management; contracts, grants, and financial management; and administrative services including safety, security, property, space, and facilities management, as well as non-information technology acquisitions.

• The Office of the Director leads the design, implementation, and evaluation of management and operational programs that respond to the Agency's needs; devises strategies to address Departmental, Office of Personnel Management, and Office of Management and Budget initiatives, including sustainability and the Agency's conference-approval process, and oversees implementation of Agency-wide efforts to address these initiatives; and conducts complex organizational and management analyses and develops major proposals and plans.
• The Division of Administrative Services provides oversight and implementation of major administrative programs including the Agency's ethics program, Continuity of Operations Plans, the Employee Transit Benefit Program, quality of worklife programs, and physical safety and security programs; manages the Agency's real property and building relocation and renovation programs, as well as Federal Occupational Health activities; oversees Public Health Service Commissioned Corps personnel activities and manages Homeland Security Presidential Directive 12 compliance; and provides administrative services including timekeeping, travel, conference and copy center management, mail, and supplies.
• The Division of Contracts Management manages all aspects of the Agency's acquisition program in accordance with Federal acquisition regulations, policies, and initiatives; oversees and implements the Agency's contract planning, solicitation, review, negotiation, award, post-award administration, payment, and contract closeout activities; develops, implements, and maintains policies and procedures for the Agency's acquisition program; provides guidance to the contracting officer representative community; and manages inter-agency agreements, the purchase card program, and acquisition workforce training and certification programs.
• The Division of Financial Management, Performance, and Evaluation provides guidance in all aspects of financial management, including Agency budget formulation and execution, and ensures integration of the budget and planning processes; manages evaluation and measurement activities for the Agency including development and implementation of the Agency's annual evaluation plan; establishes and maintains financial accounting and reporting systems and coordinates responses on budget and accounting matters with all levels of Agency management, Departmental staff, Congressional committees, and the private sector; serves as the Agency's focal point for Government Performance and Results Act activities and Program Integrity activities; and coordinates the Agency's efforts for Office of Management and Budget Circular A-123, Management's Responsibility for Internal Control.
• The Division of Grants Management provides leadership and oversight in grants management and grants management policy to the extramural research community and ´óÏóÊÓƵextramural staff through expert guidance, grant analysis and negotiation, outreach, and related information dissemination in order to promote effective stewardship of ´óÏóÊÓƵextramural funds in support of healthcare research.
• The Division of Human Capital and Resources Management provides guidance to the Agency regarding all aspects of personnel management including staff training, workforce planning and restructuring, and allocation and utilization of human capital resources; serves as liaison to the Equal Employment Opportunity service provider and to the servicing personnel office to ensure the Agency's human capital needs, including recruitment, position classification, and compensation, are met and properly executed; manages the Agency's human capital reporting function and competitive sourcing activities; and manages the Agency's awards and performance management program.
• The Division of Information Technology performs a number of information technology (IT) functions including network operations support and security; virtual desktop support; laptop support; asset inventory management; application, database, and Web server hosting; configuration management; and vulnerability mitigation and patching. The division is also a key stakeholder and contributor to ongoing Agency system and application development efforts, cybersecurity initiatives and privacy protection activities, capital planning and investment control, 508 compliance, and communication services.

OMS was formerly the Office of Performance Accountability, Resources, and Technology (OPART).